Description Probenecid is used to treat gout or gouty arthritis is chronic. Gouty arthritis is characterized by attacks of severe pain with a sudden, redness and pain in the joints, often the joint at the base of the big toe. This condition is caused by too much uric acid in the blood.
This medicine works by removing excess uric acid from the body. Probenecid does not cure gout, but after using it for several months will help prevent gout attacks. This medicine will help prevent gout attacks only during use.
Probenecid is also used to prevent or treat other medical problems that may occur if too much uric acid content in the body.
Probenecid is sometimes used with some types of antibiotics to be more effective in the treatment of infections. Probenecid is only available by prescription. This product is available in tablet dosage forms.
Dose
Different drug doses for patients according to doctor's orders or the directions on the label. The following information includes only the average doses of medication. If the dose is different, do not change it unless on the advice of a doctor.
The amount of drug used depends on the strength of the drug. The number of doses taken every day, the time allowed between doses, and the length of time to take medication depends on the medical problem suffered.
For treating gout or removing uric acid from the body:
Adults: 250 mg (one-half of the 500 mg tablets) twice daily for about a week, then 500 mg (one tablet) twice a day for several weeks. Thereafter, the dose will depend on the amount of uric acid in the blood or urine. Most people need 2, 3, or 4 tablets a day, but some people may require higher doses.
Probenecid is not required to treat gout or removing uric acid from the body in children. If a child needs this medicine, however, the dose must be determined by your doctor.
To help the antibiotics work better:
Adults: Number of probenecid will depend on the condition being treated. Sometimes, only one dose of 2 tablets are needed. Other times, the dose to 1 tablet four times a day.
Children: Dose must be determined by your doctor. Depends on the child's weight, as well as on the condition being treated. Children and adolescents may require the same amount as adults.
Storage
Drug store in a covered container at room temperature, away from heat, moisture, and direct light.
Keep from freezing.
Keep out of reach of children.
Attention
For patients taking probenecid for gout or to help remove uric acid from the body, taking aspirin or other salicylates may reduce the effect of probenecid. This will depend on the dose of aspirin or other salicylates are taken, and how often used.
Drinking too much alcohol can increase the amount of uric acid in the blood and reduce the effects of this drug. For patients with diabetes, Probenecid may cause the urine test results become invalid.
Side Effects
1. Headache
2. Joint pain, redness, or swelling
3. Loss of appetite
4. Nausea or vomiting (mild)
5. Check with your doctor immediately if any of the following side effects occur:
Very rare:
1. Fast or irregular breathing
2. Swelling of the eyelids or around the eyes
3. Shortness of breath, troubled breathing, tightness in chest, or wheezing
4. Changes in skin color that occur together with one other side effects listed here
5. Skin rash, hives, or itching occurring together with one other side effects listed here
Check with your doctor as soon as possible if any of the following side effects occur:
1. Less common
2. Bloody urine
3. Difficult or painful urination
4. Lower back or side pain
Rare
1. Cloudy urine
2. Cough or hoarseness
3. Fever
4. Pain in the back and / or ribs
5. Sores, ulcers, or white spots on lips or in mouth
6. Sore throat and fever with or without chills
7. Sudden decrease in amount of urine with
8. Swelling of face, fingers, feet, and / or lower legs
9. Swollen glands and / or pain
10.Bleeding or unusual bruising
11.Tired or unusual weakness
12.Eyes or yellow skin
13.Weight gain
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medication. Health care professionals can tell about how to prevent or reduce some side effects.
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